About the Lab

We are currently actively seeking individuals to join our team.

Studies of the basic mechanisms of Mendelian diseases offer insight into general principles that underly human health and disease. The overall long-term goal of Wangler Lab is to improve our understanding of the molecular pathogenesis of Mendelian disease by merging clinical observations, genomics and model organisms. We are currently engaged in three major efforts:

  1. Gene Discovery in Mendelian Disorders
  2. Model Organisms and the Molecular Pathogenesis of Mendelian Disorders
  3. Mendelian Disorders of the Peroxisome and Organelle Dynamics

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Recent Posts

  • THE TOP TEN RARE DISEASE PAPERS OF ALL TIME

    The doctor in training often hears, “If you hear hoofbeats, think horses not zebras” a practical guideline designed to keep a doctor focused on succeeding at the fundamentals in diagnosis and making the most likely diagnoses consistently rather than being distracted by over-thinking.  As a medical geneticist it is refreshing to dedicate a day to […]
  • Why Drosophila? Learning to Fly in the UDN

    The Undiagnosed Diseases Network has been a successful rare disease diagnosis effort. The medical geneticists involved in the seven clinical sites and the DNA sequencing teams turn to the power of next-generation sequencing which has been a powerful diagnostic tool. But like anyone doing exomes and genomes they are increasingly faced with the variant interpretation […]